The Very Highly Ionized Broad Absorption Line System of the QSO SBS1542+541

We have analyzed the broad absorption line system of the bright (V=16.5) high-redshift (z=2.361) QSO SBS1542+541 using UV spectra from the HST FOS along with optical data from the MMT and the Steward Observatory 2.3m telescope. These spectra give continuous wavelength coverage from 1200 to 8000 Angstroms, corresponding to 340 to 2480 Angstroms in the QSO rest frame. This object therefore offers a rare opportunity to study broad absorption lines in the rest-frame extreme UV. We find that the absorption system is dominated by very high-ionization species, including O VI, NeVIII, and SiXII. We also identify apparently saturated broad Lyman-series lines of order Ly-gamma and higher. There is strong evidence for partial occultation of the QSO emission source, particularly from the higher-order Lyman lines which indicate a covered fraction less than 0.2. Overall, the data suggest a correlation between a larger covered fraction and a higher state of ionization. We suggest that the different covered fractions can be explained by either a special line of sight through a disk-like geometry or by the existence of density fluctuations of a factor >2 in the BAL gas. Our photoionization models of the system indicate a large column density and high ionization state similar to that found in X-ray ``warm absorbers''.Comment: 31 pages, 13 figures, to be published in Ap

An algebraic method to solve the radial Schrödinger equation

AbstractWe propose a method of numerical integration of differential equations of the type x2y″+f(x)y=0 by approximating its solution with solutions of equations of the type x2y″+(ax2+bx+c)y=0. This approximation is performed by segmentary approximation on an interval. We apply the method to obtain approximate solutions of the radial Schrödinger equation on a given interval and test it for two different potentials. We conclude that our method gives a similar accuracy than the Taylor method of higher order

Extreme Ultraviolet Absorption Lines in LyA Forest Absorbers and the Oxygen Abundance in the Intergalactic Medium

We create stacked composite absorption spectra from Hubble Space Telescope Faint Object Spectrograph data from four quasi-stellar objects to search for absorption lines in the extreme ultraviolet wavelength region associated with LyA forest absorbers in the redshift range 1.6 < z < 2.9. We successfully detect O V 630 in LyA absorbers throughout the 10^13 to 10^16.2 cm^-2 column density range. For a sample of absorbers with 10^13.2 < N(H I) < 10^14.2 cm^-2, corresponding to gas densities ranging from around the universal mean to overdensities of a few, we measure an O V 630 equivalent width of 10.9 +/- 3.7 mA. We estimate the detection is real with at least 99% confidence. We only detect O IV 788, O IV 554, O III 833, and HeI 584 in absorbers with LyA equivalent widths > 0.6 A, which are likely associated with traditional metal-line systems. We find no evidence in any subsamples for absorption from N IV 765, NeV 568, NeVI 559, NeVIII 770, 780, or MgX 610, 625. The measured equivalent widths of O V suggest values of in the range -1.7 to -0.6 for 10^13.2 < N(H I) < 10^15 cm^-2. The lack of detectable O IV absorption except in the strongest absorption systems suggests a hard ionizing background similar to the standard Haardt & Madau spectrum. Using photoionization models, we estimate that the oxygen abundance in the intergalactic medium with respect to the solar value is [O / H] around -2.2 to -1.3. Comparing to studies of C IV, we estimate [O / C] around 0.3 to 1.2. The overabundance of oxygen relative to carbon agrees with other low-metallicity abundance measurements and suggests enrichment of the intergalactic medium by Type II supernovae.Comment: Accepted for publication in Nov 10, 2002 Ap

The Rest-Frame Extreme Ultraviolet Spectral Properties of QSOs

We use a sample of 332 Hubble Space Telescope spectra of 184 QSOs with z > 0.33 to study the typical ultraviolet spectral properties of QSOs, with emphasis on the ionizing continuum. Our sample is nearly twice as large as that of Zheng et al. (1997) and provides much better spectral coverage in the extreme ultraviolet (EUV). The overall composite continuum can be described by a power law with index alpha_EUV = -1.76 +/- 0.12 (f_nu ~ nu^alpha) between 500 and 1200 Angstroms. The corresponding results for subsamples of radio-quiet and radio-loud QSOs are alpha_EUV = -1.57 +/- 0.17 and alpha_EUV = -1.96 +/- 0.12, respectively. We also derive alpha_EUV for as many individual objects in our sample as possible, totaling 39 radio-quiet and 40 radio-loud QSOs. The typical individually measured values of alpha_EUV are in good agreement with the composites. We find no evidence for evolution of alpha_EUV with redshift for either radio-loud or radio-quiet QSOs. However, we do find marginal evidence for a trend towards harder EUV spectra with increasing luminosity for radio-loud objects. An extrapolation of our radio-quiet QSO spectrum is consistent with existing X-ray data, suggesting that the ionizing continuum may be represented by a single power law. The resulting spectrum is roughly in agreement with models of the intergalactic medium photoionized by the integrated radiation from QSOs.Comment: 14 pages using emulateapj, 15 figures, accepted for publication in Ap

A BAC-based physical map of Brachypodium distachyon and its comparative analysis with rice and wheat

<p>Abstract</p> <p>Background</p> <p><it>Brachypodium distachyon </it>(<it>Brachypodium</it>) has been recognized as a new model species for comparative and functional genomics of cereal and bioenergy crops because it possesses many biological attributes desirable in a model, such as a small genome size, short stature, self-pollinating habit, and short generation cycle. To maximize the utility of <it>Brachypodiu</it>m as a model for basic and applied research it is necessary to develop genomic resources for it. A BAC-based physical map is one of them. A physical map will facilitate analysis of genome structure, comparative genomics, and assembly of the entire genome sequence.</p> <p>Results</p> <p>A total of 67,151 <it>Brachypodium </it>BAC clones were fingerprinted with the SNaPshot HICF fingerprinting method and a genome-wide physical map of the <it>Brachypodium </it>genome was constructed. The map consisted of 671 contigs and 2,161 clones remained as singletons. The contigs and singletons spanned 414 Mb. A total of 13,970 gene-related sequences were detected in the BAC end sequences (BES). These gene tags aligned 345 contigs with 336 Mb of rice genome sequence, showing that <it>Brachypodium </it>and rice genomes are generally highly colinear. Divergent regions were mainly in the rice centromeric regions. A dot-plot of <it>Brachypodium </it>contigs against the rice genome sequences revealed remnants of the whole-genome duplication caused by paleotetraploidy, which were previously found in rice and sorghum. <it>Brachypodium </it>contigs were anchored to the wheat deletion bin maps with the BES gene-tags, opening the door to <it>Brachypodium</it>-Triticeae comparative genomics.</p> <p>Conclusion</p> <p>The construction of the <it>Brachypodium </it>physical map, and its comparison with the rice genome sequence demonstrated the utility of the SNaPshot-HICF method in the construction of BAC-based physical maps. The map represents an important genomic resource for the completion of <it>Brachypodium </it>genome sequence and grass comparative genomics. A draft of the physical map and its comparisons with rice and wheat are available at <url>http://phymap.ucdavis.edu/brachypodium/</url>.</p

Assessing the role of EO in biodiversity monitoring: options for integrating in-situ observations with EO within the context of the EBONE concept

The European Biodiversity Observation Network (EBONE) is a European contribution on terrestrial monitoring to GEO BON, the Group on Earth Observations Biodiversity Observation Network. EBONE’s aims are to develop a system of biodiversity observation at regional, national and European levels by assessing existing approaches in terms of their validity and applicability starting in Europe, then expanding to regions in Africa. The objective of EBONE is to deliver: 1. A sound scientific basis for the production of statistical estimates of stock and change of key indicators; 2. The development of a system for estimating past changes and forecasting and testing policy options and management strategies for threatened ecosystems and species; 3. A proposal for a cost-effective biodiversity monitoring system. There is a consensus that Earth Observation (EO) has a role to play in monitoring biodiversity. With its capacity to observe detailed spatial patterns and variability across large areas at regular intervals, our instinct suggests that EO could deliver the type of spatial and temporal coverage that is beyond reach with in-situ efforts. Furthermore, when considering the emerging networks of in-situ observations, the prospect of enhancing the quality of the information whilst reducing cost through integration is compelling. This report gives a realistic assessment of the role of EO in biodiversity monitoring and the options for integrating in-situ observations with EO within the context of the EBONE concept (cfr. EBONE-ID1.4). The assessment is mainly based on a set of targeted pilot studies. Building on this assessment, the report then presents a series of recommendations on the best options for using EO in an effective, consistent and sustainable biodiversity monitoring scheme. The issues that we faced were many: 1. Integration can be interpreted in different ways. One possible interpretation is: the combined use of independent data sets to deliver a different but improved data set; another is: the use of one data set to complement another dataset. 2. The targeted improvement will vary with stakeholder group: some will seek for more efficiency, others for more reliable estimates (accuracy and/or precision); others for more detail in space and/or time or more of everything. 3. Integration requires a link between the datasets (EO and in-situ). The strength of the link between reflected electromagnetic radiation and the habitats and their biodiversity observed in-situ is function of many variables, for example: the spatial scale of the observations; timing of the observations; the adopted nomenclature for classification; the complexity of the landscape in terms of composition, spatial structure and the physical environment; the habitat and land cover types under consideration. 4. The type of the EO data available varies (function of e.g. budget, size and location of region, cloudiness, national and/or international investment in airborne campaigns or space technology) which determines its capability to deliver the required output. EO and in-situ could be combined in different ways, depending on the type of integration we wanted to achieve and the targeted improvement. We aimed for an improvement in accuracy (i.e. the reduction in error of our indicator estimate calculated for an environmental zone). Furthermore, EO would also provide the spatial patterns for correlated in-situ data. EBONE in its initial development, focused on three main indicators covering: (i) the extent and change of habitats of European interest in the context of a general habitat assessment; (ii) abundance and distribution of selected species (birds, butterflies and plants); and (iii) fragmentation of natural and semi-natural areas. For habitat extent, we decided that it did not matter how in-situ was integrated with EO as long as we could demonstrate that acceptable accuracies could be achieved and the precision could consistently be improved. The nomenclature used to map habitats in-situ was the General Habitat Classification. We considered the following options where the EO and in-situ play different roles: using in-situ samples to re-calibrate a habitat map independently derived from EO; improving the accuracy of in-situ sampled habitat statistics, by post-stratification with correlated EO data; and using in-situ samples to train the classification of EO data into habitat types where the EO data delivers full coverage or a larger number of samples. For some of the above cases we also considered the impact that the sampling strategy employed to deliver the samples would have on the accuracy and precision achieved. Restricted access to European wide species data prevented work on the indicator ‘abundance and distribution of species’. With respect to the indicator ‘fragmentation’, we investigated ways of delivering EO derived measures of habitat patterns that are meaningful to sampled in-situ observations

Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase

Funding Information: Brendan M. Gabriel was supported by fellowships from the Novo Nordisk Foundation ( NNF19OC0055072 ) & the Wenner-Gren Foundation , an Albert Renold Travel Fellowship from the European Foundation for the Study of Diabetes , and an Eric Reid Fund for Methodology from the Biochemical Society . Abdalla D. Mohamed was funded initially by Sarcoma UK (grant number SUK09.2015 ), then supported by funding from Postdoctoral Fellowship Program ( Helmholtz Zentrum München, Germany ), and currently by Cancer Research UK . Publisher Copyright: © 2023 The AuthorsPeer reviewedPublisher PD

Electronic learning can facilitate student performance in undergraduate surgical education: a prospective observational study

BACKGROUND: Our institution recently introduced a novel internet accessible computer aided learning (iCAL) programme to complement existing surgical undergraduate teaching methods. On graduation of the first full cycle of undergraduate students to whom this resource was available we assessed the utility of this new teaching facility. METHOD: The computer programme prospectively records usage of the system on an individual user basis. We evaluated the utilisation of the web-based programme and its impact on class ranking changes from an entry-test evaluation to an exit examination in surgery. RESULTS: 74.4% of students were able to access iCAL from off-campus internet access. The majority of iCAL usage (64.6%) took place during working hours (08:00–18:00) with little usage on the weekend (21.1%). Working hours usage was positively associated with improvement in class rank (P = 0.025, n = 148) but out-of hours usage was not (P = 0.306). Usage during weekdays was associated with improved rank (P = 0.04), whereas weekend usage was not (P = 0.504). There were no significant differences in usage between genders (P = 0.3). Usage of the iCAL system was positively correlated with improvement in class rank from the entry to the exit examination (P = 0.046). Students with lower ranks on entry examination, were found to use the computer system more frequently (P = 0.01). CONCLUSION: Electronic learning complements traditional teaching methods in undergraduate surgical teaching. Its is more frequently used by students achieving lower class ranking with traditional teaching methods, and this usage is associated with improvements in class ranking